First, high level and activity of AhR mediates the invasive/dedifferentiated phenotype of melanoma through the direct regulation of the expression of many genes involved in invasion (COL1A1, COL6A1, COL6A2, CYR61, STC2...) (Hoek et al, 2008; Verfaillie et al, 2015) and dedifferentiation phenotypes (CCL2, NTM, NUAK2, SOX9, ABCG2...) (Rambow et al, 2018; Tsoi et al, 2018) (Appendix Table S2). This evidence concerns the gene CCN1 and melanoma.