The role of AhR transcription factor in governing the resistance and invasive capacity of melanoma cells was further highlighted after increasing the endogenous expression of AhR by CRISPR/SAM technology in melanoma cells expressing low levels of AhR protein (501Mel) or after rescuing SK28R AhR KO cell lines with a constitutively activated form of AhR, (CA‐AhR; McGuire et al, 2001). This evidence concerns the gene AHR and melanoma.