GSEA in different melanoma cell lines from the CCLE (Barretina et al, 2012), and Tsoi et al datasets (GSE80824 (Tsoi et al, 2018)) using oncogenic signature gene sets (https://www.gsea‐msigdb.org/gsea/msigdb/genesets.jsp?collection=C6) underscored that the activation of several pathways (EGFR, YAP, KRAS, TGFβ, Integrin, etc.)correlates with the mechanisms of BRAFi resistance associated with the dedifferentiation process (Appendix Fig S5A and Datasets EV1 and EV2). The gene discussed is TGFB1; the disease is melanoma.