Besides, the integrin Mac-1 expressed by microglia acting together with the endocytic receptor LRP1 in the neurovascular unit promoted thrombolytic tissue plasminogen activator (tPA)-induced platelet-derived growth factor-cc (PDGF-cc) activation, which increased the permeability of BBB following ischemic stroke (Su et al., 2017). Here, PLAT is linked to ischemic stroke.