PADI4 and ischemic stroke: DNase I and deficiency of peptidyl arginine deiminase 4 (PAD4), which can inhibit NETs, reversed tPA-mediated upregulation of cGAS.However, cGAMP application suppressed DNase I-mediated antihemorrhagic effects by downregulating the STING and INF in tPA-treated mice following ischemic stroke (Wang et al., 2021).