Different intervention treatments, including Syk inhibitor BAY61-3606, acupuncture, and MSCs engraftment, have been used to attenuate microglia-mediated neuroinflammation by impeding Mincle/Syk signaling pathway in microglia following hemorrhage stroke, ischemic stroke, and traumatic brain injury (TBI; He et al., 2015, 2022; de Rivero Vaccari et al., 2015; Liu X. Y. et al., 2018; Li Y. et al., 2021). Here, SYK is linked to ischemic stroke.