S100A8 and rheumatoid arthritis: According to the literature, the clusters mainly involved in activating the nuclear factor kappa-B (NF-κB) pathway, rheumatoid arthritis, and sarcoidosis were defined as intermediate monocytes, while another group of classical monocytes highly expressed genes such as S100A8, S100A10, and VCAN (Supplementary Figure 2E; Nahrendorf and Swirski, 2016).