Recent studies in South Africa assessed osteogenesis imperfecta (OI) type 3, which has an unusually high frequency in the Black Southern African populations (105) Out of 91 patients with a confirmed phenotypic diagnosis of OI type 3, 45% of affected individuals had a pathogenic variant of the FKBP10 gene (105). The gene discussed is FKBP10; the disease is osteogenesis imperfecta type 3.