The genetic alteration characterization of TIMP2 showed that its amplification was one of the most important single factors for alteration in liver cancer, BRCA (breast invasive carcinoma), mesothelioma, sarcoma, lung adenocarcinoma, LGG, CRC, uveal melanoma, PCPG, esophagus cancer, pancreas cancer, thyroid cancer, GBM, and ccRCC. This evidence concerns the gene TIMP2 and lung adenocarcinoma.