The genetic alteration characterization of TIMP2 showed that its amplification was one of the most important single factors for alteration in liver cancer, BRCA (breast invasive carcinoma), mesothelioma, sarcoma, lung adenocarcinoma, LGG, CRC, uveal melanoma, PCPG, esophagus cancer, pancreas cancer, thyroid cancer, GBM, and ccRCC. The gene discussed is TIMP2; the disease is mesothelioma.