In this study, we used the KEGG pathways and GO terms to describe specific pathway and biological process of LZTR1 and LZTR1-related genes in different cancers and found that these gene may play important roles in “hedgehog signaling pathway,” “ubiquitin mediated proteolysis,” “human immunodeficiency virus 1 infection,” and other pathways. This evidence concerns the gene LZTR1 and cancer.