Sakakibara et al. [48] found that 68% of LCNEC patients (30/44) and 92% of SCLC patients (72/78) expressed INSM1, and also found that INSM1 was positive in 9 of 12 SCLC patients who did not express neuroendocrine phenotypic markers, suggesting that INSM1 was superior to phenotypic markers. The gene discussed is INSM1; the disease is large cell neuroendocrine carcinoma.