And the mutations of tumor protein p53 (TP53), RB1, serine/threonine kinase 11 (STK11), kelch like ECH associated protein 1 (KEAP1) and kirsten rat sarcoma viral oncogene homologue (KRAS) also occurred in LCNEC. The gene discussed is KEAP1; the disease is large cell neuroendocrine carcinoma.