Bari et al. [52] sequenced the frozen tissues of 8 cases of SCLC and 8 cases of LCNEC, and found that caudal type homeobox 2 (CDX2), Villin 1 (VIL1) and brain-specific angiogenesis inhibitor 3 (BAI3) were differentially expressed in the two tumors. The gene discussed is CDX2; the disease is large cell neuroendocrine carcinoma.