FZD7 and intrahepatic cholangiocarcinoma: For instance, CircACTN4 was demonstrated to be upregulated in ICC (intrahepatic cholangiocarcinoma) patients, acting as a molecular sponge of miR-424-5p and interacting with YBX1, to transcriptionally activate FZD7, thereby promoting proliferation and metastasis of ICC (Chen et al., 2022).