The release of BIIB021 after NIR light irradiation not only reduces cellular tolerance to heat but also decreases mitochondrial membrane potential, which resulting in key endogenous apoptotic factors affection (Cyt-C, Caspase-9, Bcl-2 and Bax), synergistically exerting the effect of low-temperature PTT to strike tumor cells down (Zhang et al., 2021). Here, BCL2 is linked to neoplasm.