Additionally, pyroptotic ECs contribute to endothelial dysfunction in terms of elevating the permeability of endothelial monolayer and increasing the migration and deposition of lipids, monocytes, and SMCs into the intima accompanied by inflammatory cytokine release, and canonical pathway of NLRP3 is the main mechanism of ECs pyroptosis in atherosclerosis [16]. This evidence concerns the gene NLRP3 and atherosclerosis.