The activated ECs at the sites of inceptive atherosclerosis up-regulate the expression of P-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which are critical for attracting inflammatory cells, such as monocytes, for trans-endothelial recruitment [90]. The gene discussed is VCAM1; the disease is atherosclerosis.