For instance, it has been reported that mice with cardiomyocyte-restricted constitutive activation of the NLRP3 inflammasome have increased atrial ectopic activity and AF susceptibility, as well as enhanced mRNA expression of key ion channel subunits (RyR2, Kv1.5, GIRK1, and GIRK4) (6). This evidence concerns the gene KCNJ5 and atrial fibrillation.