The organism can activate the NLRP3 inflammasome in response to infection, tissue damage, and oxidative stress, and then this activated complex transforms the cystatin-1 precursor into an active 20 kDa fragment that enables to promote of the IL-18 precursor into mature IL-18 and facilitate its release, which is considered significant in the initiation of inflammation (24). The gene discussed is NLRP3; the disease is infection.