All MDSC subsets (immature MDSC, G-MDSC, M-MDSC) were higher in patients VS. HD (p = 0.03, p = 0.02, p 0.04), and higher MDSC percentages were present in non-responders. CD34+ immature MDSC were predictive for a short PFS in HL patients (p = 0.03). This evidence concerns the gene CD34 and Hodgkins lymphoma.