CD4 and dermatitis: However, DTR-WT mice with DT injection, lacking r-Langerin+ dDCs and BM-derived i-Langerin+ dDCs, demonstrated significantly alleviated skin inflammation, as evidenced by an obvious improvement in gross appearance (Figure 6B), decreased ear thickness (Figures 6C, D), decreased level of TEWL, less scratch behavior (Figures 6E–G) and decreased number of infiltrating Gr1+, CD4+ and CD8+ cells (Figure 6H).