APOE and metabolic dysfunction-associated steatotic liver disease: Data reported above support the following conclusions: in healthy murine and human livers the number of C1q-ApoE complexes is low or absent; C1q-ApoE complexes form around portal triads in which activated myeloid cell aggregates emerge and to a lesser degree in the liver parenchyma; C1q-ApoE complexes are abundant in both portal triads and the liver parenchyma in NAFLD livers; numerous C1q-ApoE complexes arise in HepC and HepB/C-infected livers with prominent expression in both portal triads and the liver parenchyma.