Since the activation of TLR7 pathway inhibits viral replication in lungs and reduces airway hyperreactivity triggered by viral infections, synthetic TLR7 agonists [e.g., imiquimod (R837), resiquimod (R848), and 8-hydroxyadenine derivatives] have also been investigated as antiviral drugs (105). The gene discussed is TLR7; the disease is viral infectious disease.