The transcript factors Foxo1, Cdkn2d, Foxo3, Ep300, Pias1, Nfkb1, Creb1, Bcl6, Ppp3cb, Mef2a, and Irf5 are lower in acute monocyte leukemia than those of normal human monocytes but that the transcript factor Nfat4, Ifnar2, Irf7, and Cebpb are higher in acute monocyte leukemia than those of normal human monocytes (Figure 5C). This evidence concerns the gene PIAS1 and acute monocytic leukemia.