By analyzing the RNA-seq data of acute monocytic leukemia, we found that the transcriptional expression of the transcription factors Foxo1, Cdkn2d, Foxo3, Ep300, Pias1, Nfkb1, Creb1, Bcl6 and Ppp3cb are reversely downregulated in acute monocytic leukemia compared with monocytes in healthy individuals. The gene discussed is PIAS1; the disease is acute monocytic leukemia.