RUNX2 and hereditary spherocytosis: It has also been reported that mutations in the human Ank1 (74, 75), Runx2 (76–79), Nfia (80), Hmga2 (81), and Klf1 (82, 83) genes caused diseases of the hematopoietic system, such as hereditary spherocytosis, fetal anemia, myelodysplastic syndrome, and acute erythroleukemia.