In the study of the hypoxic microenvironment of cancer, mitochondrial DNA-encoded Cytb was ~30% lower in Lewis lung carcinoma hearts (15), heteroplasmic changes were found in ND1 and CYTB in epithelioma glandulae sebacei and in CYTB in lymphoma centroblasticum (16). This evidence concerns the gene MT-CYB and Carcinoma, Lewis Lung.