The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling (30), HIF-1α facilitates osteocyte-mediated osteoclastogenesis by activating JAK2/STAT3 pathway (31), which indicated that HIF regulated the expression of STAT3, but the regulation of HIF on STAT3 should be further studied, which is related to hypoxia adaptation in yak. Here, STAT3 is linked to neoplasm.