NUP98 and acute myeloid leukemia: NUP98 fusion oncoproteins arise through gene translocations that fuse the N-terminal protein coding region of NUP98 to C-terminal coding regions of > 30 different genes that commonly encode DNA binding or chromatin binding protein domains (Michmerhuizen et al., 2020) and are oncogenic drivers in ∼10% of pediatric cases of acute myeloid leukemia (AML) (Michmerhuizen et al., 2020).