Recently, our group demonstrated that ASPM was highly expressed both in hepatitis B virus (HBV) (+) HCC and HBV (+) non-cancerous expression profiles, and with the progression of hepatitis B cirrhosis, ASPM showed significant genetic alteration potential and overexpression tendency, suggesting that ASPM might involve in the malignant progression of hepatitis B cirrhosis. Here, ASPM is linked to hepatocellular carcinoma.