FEN1 and non-small cell lung carcinoma: For example, expression signature of six genes including UBE2C, TPX2, MCM2, MCM6, FEN1, and SFN were associated with prognosis in stage I NSCLC patients (Kadara et al., 2009), but in another research, a totally different 15-gene signature was reported as prognostic markers in early-stage NSCLC patients (Zhu et al., 2010).