Some of the predicted master regulators, including PTTG1 (Li et al., 2013), RFC4 (Liu et al., 2021), TRIP13 (Zhang et al., 2019), BUB1B (Chen et al., 2015), TTK (Tsai et al., 2020), and ZWINT (Peng et al., 2019) are capable of promoting migration, invasion, and metastasis of lung cancer cells. The gene discussed is TRIP13; the disease is lung carcinoma.