Some of the predicted master regulators, including PTTG1 (Li et al., 2013), RFC4 (Liu et al., 2021), TRIP13 (Zhang et al., 2019), BUB1B (Chen et al., 2015), TTK (Tsai et al., 2020), and ZWINT (Peng et al., 2019) are capable of promoting migration, invasion, and metastasis of lung cancer cells. This evidence concerns the gene RFC4 and lung cancer.