Based on the previous reports, AKT1 serine/threoe kinase is a key autophagy target of the PI3K signaling pathway, and plays a role in the differentiation of peripheral B cells and in T-cell homeostasis in SLE patients (Juntilla and Koretzky, 2008; Garcia-Rodriguez et al., 2012). This evidence concerns the gene AKT1 and systemic lupus erythematosus.