In summary, the inhibitory effect of IGU with hub targets act on SLE may be involved in the immune cell regulation process, apoptosis, regulating immune cell function, angiogenesis, and endoplasmic reticulum stress through the regulation of MARK, PI3K/AKT, FoxO, and chemokine signaling pathways. This evidence concerns the gene MARK1 and systemic lupus erythematosus.