We found three genes (PLK1, TOP2A, RAD51) are in common with Prolaris prostate cancer signature (Crawford et al., 2014), two genes (BCL2 and GAPDH) with the breast cancer signature Oncotype Dx (Paik et al., 2004), other two genes (TP53, PTEN) with ColoNext (Colon Cancer Genetic Testing, 2021), one gene (GMPS) in common with the breast cancer signature Mammaprint (van ’t Veer et al., 2002), and finally one gene (BCL2) with the Prosigna breast cancer test PAM50 (Parker et al., 2009). The gene discussed is TOP2A; the disease is breast cancer.