Insulin resistance (IR) is the major complication associated with diabetes (3) and is characterized by the impaired response to several biological mechanisms, i.e., downregulation of the receptor, abnormal GLUT-4 function, defects in ser/thr residues of insulin receptors genetically, defects in insulin receptor proteins, and abnormal functioning of PIP3 (4). The gene discussed is INSR; the disease is diabetes mellitus.