Xiao et al. further confirmed that the protective role of ALR against steatosis occurred via the inhibition of calcium transport from the ER to mitochondria, and the inhibition of ER stress by ALR was associated with an interrupted interaction between Bcl2 and the inositol 1,4,5-trisphosphate receptor (IP3R) (Xiao et al., 2018). This evidence concerns the gene GFER and steatosis.