The administration of recombinant renalase produces a powerful and rapid hypotensive effect on rats (Schiffrin et al., 2007; Wang et al., 2017) and reduces plasma NE, left ventricular hypertrophy (LVH), and cardiac fibrosis in 5/6 nephrectomy hypertensive CKD rats (Baraka and El Ghotny, 2012). The gene discussed is RNLS; the disease is chronic kidney disease.