AGT and chronic kidney disease: A study conducted on our CKD rat as alluded to earlier, the LPK model, revealed that acute blockade of AT1 receptor by IV losartan ameliorated not only BP but also improved baroreflex control of splanchnic SNA and further reduced the splanchnic, renal and lumbar SNA chemoreflex outflows in this CKD model (Yao et al., 2015); findings which thus support the role of Ang II in perpetuating the peripheral SNS reflexes during CKD progression.