Indeed, animal studies, using models of hypertension, heart and kidney disease and obesity, have shown that AT2 receptor activation promotes diuresis and natriuresis, lowers BP, inhibits vascular calcification, suppresses chronic inflammation, mitigates cardiac damage, and improves renal structural and functional abnormalities (Johnson and Malvin, 1977; van der Mark and Kline, 1994; Gelosa et al., 2009; Kukida et al., 2019; Wang et al., 2020; Gavini et al., 2021). The gene discussed is AGTR2; the disease is hypertensive disorder.