In the kidney, ET-1 via ETA facilitates fibrotic pathways to cause nephropathy progression in conditions such as hypertension, diabetes, dyslipidemia, glomerular sclerosis, and autosomal dominant PKD (Wesson, 2006; Dhaun et al., 2011; Kohan and Barton, 2014; Raina et al., 2020). The gene discussed is EDN1; the disease is kidney disorder.