AGT and chronic kidney disease: In CKD secondary to vascular disease, diabetes or PKD, reports have indicated that in areas of renal injury or ischemia induced by scarring, there is a greater production of local and intra-renal Ang II, which then exacerbates systemic hypertension (Acosta, 1982; Rosenberg et al., 1994; Fonseca et al., 2014).