It has been established that the phosphatonin fibroblast growth factor-23 (FGF-23) has a central role in the regulation of phosphate-vitamin D homeostasis, as this FGF-23 concentration increases secondary to hyperphosphatemia in CKD (Slatopolsky et al., 1999; Six et al., 2020). This evidence concerns the gene FGF23 and hyperphosphatemia.