SIRT3 and liver dysplastic nodule: Sirtuin3 (SIRT3) is a mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that can effectively prevent the development of DN, whether by regulating the AMPK/SIRT3 signaling pathway or the SIRT3/SOD2 signaling pathway (Liu et al., 2019d; Guan et al., 2021; Wongmekiat et al., 2021; Li et al., 2022a).