Besides, inhibition of EZH2/EGR1/TXNIP/NLRP3 signaling pathway and Nrf2/TXNIP/NLRP3 signaling pathway can slow down the progression of DN (Dai et al., 2021; Abd El-Khalik et al., 2022). The gene discussed is NFE2L2; the disease is liver dysplastic nodule.