Hyperglycemia, hyperlipidemia, and hyperuricemia can all activate the NLRP3 inflammasome, and NLRP3 knockout (KO) can attenuate glomerular hypertrophy, glomerulosclerosis, and mesangial matrix expansion in streptozotocin (STZ)-induced diabetic mice (Qiu and Tang, 2016; Wu et al., 2018). This evidence concerns the gene NLRP3 and glomerulosclerosis.