Meanwhile, in a streptozotocin (STZ)-induced diabetic mouse model, upregulation of PTEN can reduce the phosphorylation levels of phosphoinositide 3-kinases (PI3K) and protein kinase B (Akt/PKB), thereby alleviating inflammation and renal interstitial fibrosis in DN (Song et al., 2020). This evidence concerns the gene AKT1 and liver dysplastic nodule.