Recently, the experiments in other cells have also found that Kuijieling (KJL), rosuvastatin (RVS), vitamin D (VD), and Kanglexin (KLX) can also inhibit NLRP3 inflammasome-mediated pyroptosis, but whether these drugs act on pyroptosis in DN kidney is still lacking specific research (Bian et al., 2020b; Chen et al., 2021; Zhang et al., 2021f; Jie et al., 2021). The gene discussed is NLRP3; the disease is liver dysplastic nodule.