Recently, AMPK was used to inhibit the activation of NF-κB via silent mating type information regulation-2 homolog-1 (SIRT1), and the expression of NLRP3, caspase-1, IL-1β, and GSDMD-N were observed to decrease in podocytes of DN mice (Li et al., 2020a). This evidence concerns the gene NFKB1 and liver dysplastic nodule.