PLEKHO1 and osteoporosis: Our previous study found that CKIP-1 regulates bone metabolism (Liu et al., 2018; Yang et al., 2018) and that QGY acts as an anti-osteoporosis agent by inhibiting CKIP-1 and Akt binding in osteoblasts, activating the Akt/mTOR signaling pathway, inhibiting cellular autophagy, promoting osteogenic differentiation, and promoting osteoporosis (Yuan et al., 2022).