Many studies showed the disorders of Nrf2 and NF-κB signaling pathways in IBD patients or NSAIDs-induced gastrointestinal damage, and Nrf2 activation was involved in the protective effect on indomethacin-induced damage of IEC-6 cells (Harada et al., 2015; Wardyn et al., 2015; Sivandzade et al., 2019). The gene discussed is GABPA; the disease is inflammatory bowel disease.