CDK7 and neoplasm: In the H226 xenograft, tumor growth was suppressed by DCA/Nic and partially mediated by apoptosis (downregulation of Bcl-2 and XIAP), anti-proliferation (decrease in expression of PCNA and Akt), G2/M arrest (CDK7 downregulation) and suppressed migration (decline in expression β-catenin).