The cannabinoid receptor 1 (CB1) is the most abundantly expressed GPCR in the brain (Marsicano and Lutz, 1999) and it is a therapeutically useful target involved in a wide variety of physiological processes such as: metabolic regulation, craving, pain, and anxiety (Mackie, 2006; Pacher et al., 2006; An et al., 2020)). This evidence concerns the gene CNR1 and Anxiety.