Last but not the least, IHC assay provided that knockdown of circ-LIMK1 or DDP treatment could reduce the expression of Ki67 and HMGA1 in tumor tissues, and Ki67 and HMGA1 were lowest after knockdown of circ-LIMK1 and treatment with DDP (Figure 8h and i). The gene discussed is HMGA1; the disease is neoplasm.