Expressions of circ-LIMK1, miR-512-5p, and HMGA1 mRNA were examined by RT-qPCR, the results suggested that knockdown circ-LIMK1 could reduce the expression of circ-LIMK1 in tumor tissues and the tumor tissues after treatment with DDP (Figure 8d); the expression of miR-512-5p was up-regulated after knockdown of circ-LIMK1 in tumor tissues and the tumor tissues after treatment with DDP (Figure 8e), and the mRNA level of HMGA1 was markedly declined in tumor tissues and the tumor tissues after treatment with DDP (Figure 8f). This evidence concerns the gene HMGA1 and neoplasm.