Further studies found that miR-512-5p expression was reduced in DDP-resistant lung adenocarcinoma cells, and miR-512-5p absence could overturn the influence of circ-LIMK1 knockdown on the process of DDP resistance of lung adenocarcinoma cells, which also provided important ideas for mechanism research on DDP resistance. The gene discussed is LIMK1; the disease is lung adenocarcinoma.