Tumor cells and surrounding tissues secrete a variety of proinflammatory factors (such as IL-1 and 6 and TNF) to promote the expression of proinflammatory factors in the hypothalamus, leading to the inactivation of NPY/AgRP neurons and activation of POMC/CART neurons, resulting in anorexia and other symptoms [40]. The gene discussed is TNF; the disease is Anorexia.