Social and cognitive deficits are largely, but not completely rescued upon adult reinstatement of Grin1 (Mielnik et al., 2020) and fully rescued upon Shank3 reinstatement (Mei et al., 2016), but motor and anxiety deficits are only partially rescued upon Grin1 reinstatement (Mielnik et al., 2020) and not rescued upon Shank3 reinstatement (Mei et al., 2016). The gene discussed is SHANK3; the disease is Anxiety.