The two regions with the highest PPA_4 chr9:20464018-22205246 around CDKN2A and chr6:19207758-21683982 around CDKAL1 were both significantly associated with endometriosis and melanoma at a genome-wide threshold but different index SNPs were reported in the different diseases (27, 28), consistent with the current GWAS-PW results. Here, CDKN2A is linked to melanoma.