GNRH1 and endometriosis: By developing PK-PD models with additional mechanistic detail, researchers have been able to identify endometriosis patients with a genetic favorability for a GnRH antagonist (41), predict changes in bone mineral density following long-term GnRH antagonist treatment of endometriosis (42), and interrogate the role of chosen delivery method in the efficacy of combination progestin therapies (43).