INS and type 2 diabetes mellitus: Given that FFAR1 mRNA and protein expression are reduced in the islets of diabetic mice (35) and an FFAR1 agonist improved glucose and lipid metabolism in obese mice (36), it is conceivable that altered DNA methylation near the TSS of the FFAR1 gene could be associated with alterations in insulin secretion and glucose homeostasis in adolescents with T2D, although this hypothesis requires further investigation.