Some of these genes have biological relevance to T2D, such as FFAR1, USF2, C1QTNF9, Arylsulfatase A (ARSA), Chromodomain Helicase DNA Binding Protein 8 (CHD8), Protocadherin Alpha 1 (PCDHA1) and Natriuretic Peptide B (NPPB) (Table 3). The gene discussed is ARSA; the disease is type 2 diabetes mellitus.