Since the first description of fibulin-3 in pancreatic adenocarcinoma (24) and malignant glioma (17), this protein has been repeatedly demonstrated as a pro-tumoral factor in several cancer types, enhancing malignant features such as tumor cell proliferation, invasion and metastasis (17, 18, 20, 22, 25); tumor “stemness” (36, 50); angiogenesis (21, 39); and chemoresistance (36, 51). This evidence concerns the gene EFEMP1 and malignant glioma.