GO and KEGG pathway enrichment analyses for all m6A hypo- and hyper-methylated mRNA/ncRNA demonstrated that abnormal m6A methylation played an important role in the immune response and tumor-related processes, including positive regulation of nuclear factor-κB (NF-κB) transcription factor activity, angiogenesis and cell-substrate adhesion (Figures 1G, S1F). The gene discussed is NFKB1; the disease is neoplasm.