TRIM2 (tripartite motif-containing 2), a member of the TRIM superfamily, is involved in a variety of physiological processes, including DNA repair, cell proliferation and pluripotency, transcription and signal transduction, and is also associated with carcinogenic effects in several malignancies, such as lung cancer (38) and pancreatic cancer (39). This evidence concerns the gene TRAT1 and lung carcinoma.