TRIM2 (tripartite motif-containing 2), a member of the TRIM superfamily, is involved in a variety of physiological processes, including DNA repair, cell proliferation and pluripotency, transcription and signal transduction, and is also associated with carcinogenic effects in several malignancies, such as lung cancer (38) and pancreatic cancer (39). The gene discussed is TRIM2; the disease is lung carcinoma.