DOCK4 and neoplasm: We further verified the expression of TRIM2 and DOCK4 based on RNA-seq data from 5 LUAD patients, which suggested that TRIM2 was up-regulated and DOCK4 was down-regulated in tumor tissues compared with NATs (Figure 5G), which was consistent with the results from the GEPIA2 database (483 tumor and 347 normal samples) (Figure S5E).