Finally, we show the 10 proteins that differed most in disease relative to normal (Supplementary Figures S2G–I), with EMG1, IFI6 are the most up-regulated and down-regulated DEP for MCI relative to normal, ZCD2, IFI6 are the most up-regulated and down-regulated DEP for AD, and CCT7, RANBP6 are the most up-regulated and down-regulated DEP for PD. The gene discussed is CISD2; the disease is Alzheimer disease.