Figures 3, 4 illustrate two representative cases from visual analysis and the machine-learning model. The first case is an IDH-wt patient (Figure 3), who is 43 years old (age at diagnosis), female with a histopathological grade IV glioma. The second one is a patient with an IDH mutation (Figure 4), who is 22 years old (age at diagnosis), male with histopathological grade III glioma. This evidence concerns the gene IDH1 and central nervous system cancer.