IDH2 and glioma: Figures 3, 4 illustrate two representative cases from visual analysis and the machine-learning model. The first case is an IDH-wt patient (Figure 3), who is 43 years old (age at diagnosis), female with a histopathological grade IV glioma. The second one is a patient with an IDH mutation (Figure 4), who is 22 years old (age at diagnosis), male with histopathological grade III glioma.