Van et al. (2020) used a combination of discovery and targeted peptidomics workflows, alongside specific selection strategies to finally distinguish 7 C-terminal peptides (UMOD1-UMOD7, most significantly SGSVIDQSRVLNLGPITRK, 588–606) from uromodulin as biomarkers for type-1-diabetes. Here, UMOD is linked to type 1 diabetes mellitus.