We used epigenetic LISA to identify key transcription factors that bind genes significantly upregulated in the FOXO3 high GBM tumor samples.46 LISA analysis revealed a significant enrichment for members of the kruppel-like zincfinger, Sp1 zincfinger, and SOX families, as well as a member of the polycomb repressive complex (Figure 3A and Table S1). The gene discussed is SP1; the disease is glioblastoma.