We find that these FOXO3-associated transcriptional networks correlate in GSCs and old NSCs with a particular enrichment for metabolic pathways, including mitochondrial functions, which have also recently been identified in a pathway-based subtype of GBM.42 Overall, we find that FOXO3 shares a common transcriptional network in aging and cancer that is associated with the stabilization of metabolic states. This evidence concerns the gene FOXO3 and cancer.