We further confirmed these findings in GBM tumor samples that were enriched for markers of stemness in the Ivy GAP.43 Consistent with our observations, FOXO3 levels in the Ivy GAP GSCs were associated with cell cycle arrest (high FOXO3) and mitochondrial oxPhos and nucleotide metabolism (low FOXO3; Figure S5A). Here, FOXO3 is linked to neoplasm.