We selected SOX2 as a marker of stem-like cells because it has been used as a GSC marker in a number of studies and has been proposed to be a therapeutic target in GBM.23,71,72 Many cases exhibited strongly positive FOXO3 staining, where FOXO3 was clearly localized to the nucleus of tumor cells (Figure 2A–C). This evidence concerns the gene FOXO3 and neoplasm.