These transcriptional programs appear to impact GBM characteristics, as GBMs in the TCGA database with low FOXO3 levels were frequently characterized as mesenchymal tumors that tend to be more migratory (Figure 5F), and those with high FOXO3 levels were more often associated with the classical GBM transcriptional profile. Here, FOXO3 is linked to mesenchymal cell neoplasm.