To understand FOXO3’s function in GBM, we analyzed publicly available RNA-seq data from 169 human GBM tumor samples from the Cancer Genome Atlas (TCGA).69 We first split the GBM tumor samples based on FOXO3 expression level and compared tumors in the top quartile of FOXO3 expression (FOXO3 high) with those in the bottom quartile (FOXO3 low). This evidence concerns the gene FOXO3 and neoplasm.