PRL and obesity due to melanocortin 4 receptor deficiency: Among the distinct lifestyle predictors analyzed (obesity, physical inactivity, smoking, alcohol use, marijuana use), marijuana use revealed to provoke the most substantial effect on serum estradiol (Table 4: ß = −0.35, p < 0.01) and prolactin levels (Table 5: ß = 0.30; p < 0.01).