Driver mutations within uterine fibroids have been elucidated in the past two decades as a mutated Mediator Complex subunit 12 (MED12), mutations in the gene encoding the DNA-binding high mobility group AT-hook 2 (HMGA2), fumarate hydratase (FH) deficiency, and mutations in the genes encoding the collagen type IV α5 chain/collagen type IV α6 chains (Col4A5/A6) (59). The gene discussed is MED12; the disease is familial hyperaldosteronism.