There has been minimal research thus far regarding reproductive manifestations in TSC, but it is known that intact mTOR activity is key in regulating several female reproductive processes including folliculogenesis, oocyte meiotic maturation, ovarian somatic cell proliferation, steroidogenesis, pubertal onset, ovarian aging, endometrium changes, and embryonic development (9). The gene discussed is MTOR; the disease is tuberous sclerosis.