The Copenhagen City Heart Study, which included 9,330 men and women who were followed up for 10 years, showed a stepwise increase in the risk of myocardial infarction (MI), with increasing Lp(a) and extreme Lp(a) levels predicting a 3–4-fold increase in risk of MI in the general population (Kamstrup et al., 2008). This evidence concerns the gene LPA and myocardial infarction.