One of the most studied paradigms is PINK1-Parkin dependent mitophagy as these genes encode a ubiquitin kinase (PINK1; PARK6) and RBR E3 ubiquitin ligase (Parkin; PARK2) that are mutated in rare forms of early onset PD (McWilliams and Muqit 2017; Whitworth and Pallanck, 2017). This evidence concerns the gene PRKN and Parkinson disease.