LRRK2 and Parkinson disease: Importantly, familial PD continues to provide surprises in the mitophagy field: recent work has identified the PD-related kinase LRRK2 as a bona fide regulator of physiological mitophagy in mammals, with increased kinase activity leading to diminished levels of mitophagy, and loss of LRRK2 triggering enhanced mitophagy in vivo (Singh F. et al., 2021).