Epigenetic associations between SOCS3-cg18181703 and C-reactive protein, inflammatory bowel disease, type-2 diabetes and cognitive abilities (Chambers et al., 2015; Ligthart et al., 2016; Marioni et al., 2018; Juvinao-Quintero et al., 2021) also suggest potential pleiotropic effects of SOCS3 gene. This evidence concerns the gene SOCS3 and inflammatory bowel disease.