High-throughput pyrosequencing analysis was used to quantify, in blood DNA obtained from PCa and healthy control cases, the percentage of DNA methylation levels in a panel of eight genes (retinoic acid receptor beta2 (RARβ2), TIMP metallopeptidase inhibitor 3 (TIMP3), secreted protein acidic and cysteine rich (SPARC), cadherin 13 (CDH13), HIN1, long interspersed element class 1 (LINE1), cytochrome B5 reductase 2 (CYB5R2) and dopamine receptor D2 (DRD2)). The gene discussed is TIMP3; the disease is posterior cortical atrophy.